Nicotine. Of all the drugs, I would argue that this is the most addictive. It's a purely chemical addiction. There is nothing gained from it. No high, no euphoria. It may calm the nerves, but the only reason your nerves need calming in the first place is because of the addiction.
Most smokers are fully aware that they are inhaling poison. Most don't care. I suppose people smoke for the same reason people drink. At any rate, Bill Hicks on smoking:
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